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Medical Studies/Editorials

ARPO has compiled a list of medical studies/editorials related to prescription opioids below.

Featured Journal

  • Journal of Medical Toxicology, December 2012, Volume 8, Issue 4; special issue devoted to opioids, Link to Journal
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  • Agrawal,S. M.D., Brennan, N. M.P.P., Budetti, P. M.D., J.D.  The Sunshine Act — Effects on Physicians. N Engl J Med 2013; 368:2054-2057May 30, 2013DOI: 10.1056/NEJMp1303523.
  • Alam, Asim; Gomes, Tara; Zheng, Hong; Mamdani, Muhammad M.; Juurlink, David N.; Bell, Chaim M. Long-Term Analgesic Use After Low-Risk Surgery. Archives Internal Medicine 2012; 172(5): 425-430. Abstract
  • Alexander, G.C.; Kruszewski, S.P.; Webster, D.W.; Rethinking Opioid Prescribing to Protect Patient Safety and Public Health. JAMA, November 14, 2012; Vol 308, No.18: 1865-1866. Abstract
  • Alford, Daniel P.  MD, MPH.  Weighing In on Opioids for Chronic Pain The Barriers to Change. JAMA. 2013;310(13):1351-1352. doi:10.1001/jama.2013.278587. Editorial 
  • Allan, G. Michael; Dhalla, Irfan A.; Ivers, Noah; Opioids for osteoarthritis pain: benefits and risks. Canadian Family Physician (CFP) December 2012; vol. 58 no. 12 e708  Link to article
  • Anderson, T.S. MD; Dave, Shravan BS; Good, Chester B. MD, MPH; Gellad,Walid F. MD, MPH.  Academic Medical Center Leadership on Pharmaceutical Company Boards of Directors. JAMA. 2014;311(13):1353-1355. doi:10.1001/jama.2013.284925. Research Letter
  • Arie, Sophie. Working with the Drug Industry How a marriage with big pharma ended in divorce. BMJ 2013;347:f6062  Published October 8, 2013  Article
  • Bailey JA, Hurley RW, Gold MS. Crossroads of pain and addiction.  Pain Med. 2010 Dec;11(12):1803-18. doi: 10.1111/j.1526-4637.2010.00982.x. Epub 2010 Oct 28.  Abstract
  • Ballantyne, J.C. Opioids for chronic pain: taking stock. Pain 2006; 125: 3-4.
  • Ballantyne, JC. Pain medicine: Repairing a fractured dream. Anesthesiology 2011; 114(2): 243-246.
  • Ballantyne JC, Shin NS. Efficacy of opioids for chronic pain: a review of the evidence. Clin J Pain 2008; 24:469-78.
  • Ballantyne, J.C. “Safe and Effective When Used As Directed”: The Case of Chronic Use of Opioid Analgesics. Journal of Medical Toxicology, Vol. 8, Issue 4, December 2012, ISSN: 1556–9039 (print) 1937 – 6995 (online) (Print) 1937-6995 (Online)
    Abstract
  • Banjo, Oluwajenyo MPH, Tzemis, Despina MPH, Al-Qutub, Diana MPH, Amlani, Ashraf MPH, Kesselring, Sarah MPH, Buxton, Jane A. MBBS, MHSc.  A quantitative and qualitative evaluation of the British Columbia Take Home Naloxone program.  doi: 10.9778/cmajo.20140008  cmajo August 21, 2014 vol. 2 no. 3 E153-E161. Article
  • Banta-Green CJ, Merrill JO, Doyle SR, Boudreau DM, Calsyn DA. Measurement of opioid problems among chronic pain patients in a general medical population. Drug and Alcohol Dependence 2009; 104:43-49.
  • Baumblatt JA, Wiedeman C, Dunn JR, Schaffner W, Paulozzi LJ, Jones TF. High-Risk Use by Patients Prescribed Opioids for Pain and Its Role in Overdose Deaths. JAMA Intern Med. 2014 Mar 3. doi: 10.1001/jamainternmed.2013.12711. Abstract
  • Beauchamp GA, Winstanley EL, Ryan SA, Lyons MS.  Moving beyond misuse and diversion: the urgent need to consider the role of iatrogenic addiction in the current opioid epidemic. Am J Public Health. 2014 Nov;104(11):2023-9. doi: 10.2105/AJPH.2014.302147. Epub 2014 Sep 11. Abstract
  • Becker WC, Fiellin DA, Gallagher RM, Barth KS, Ross JT, Oslin DW. The association between chronic pain and prescription drug abuse in Veterans. Pain Medicine 2009; 10:531-536.
  • Betses, Mitch R.Ph., Brennan, Troyen M.D., M.P.H.  Abusive Prescribing of Controlled Substances — A Pharmacy View.  August 21, 2013DOI: 10.1056/NEJMp1308222.  Article
  • Billioti de Gage, Sophie et al. Benzodiazepine use and risk of Alzheimer’s disease: case-control study. BMJ 2014;349:g5205; September, 2014.  Article
  • Bohnert, A.S. PhD; Valenstein, M. MD; Bair, M.J. MD; Ganoczy, D. MPH; McCarthy, J.F. PhD; Ilgen, M.A., PhD; Blow, F.C. PhD.  Association Between Opioid Prescribing Patterns and Opioid Overdose-Related Deaths. JAMA April 6, 2011, Vol 305, No. 13  Article
  • Boscarino JA, Rutstalis M, Hoffman SN, Han JJ, Erlich PM, Gerhard GS, Stewart WF. Risk factors for drug dependence among out-patients on opioid therapy in a large US health-care system. Addiction 2010; 105:1776-1782. Abstract
  • Broyles, Lauren M. PhD RNabc*, Binswanger, Ingrid A. MD MPHde, Jenkins, Jennifer A. MPHa, Finnell, Deborah S. DNS PMHNPf, Faseru, Babalola MD MPHgghi, Cavaiola, Alan PhDj, Pugatch, Marianne MSWklmn & Gordon, Adam J. MD MPHabc Confronting Inadvertent Stigma and Pejorative Language in Addiction Scholarship: A Recognition and Response; Substance Abuse Journal, DOI:10.1080/08897077.2014.930372  Article
  • Cain DM, Loewenstein G, Moore DA; The Dirt on Coming Clean: Perverse Effects of Disclosing Conflicts of Interest.  University of Chicago, The Journal of Legal Studies Volume 34 (1) January, 2005. Article 
  • Calcaterra, S., Glanz, J.  Binswanger, I. A.  National trends in pharmaceutical opioid related overdose deaths compared to other substance related overdose deaths: 1999–2009☆ Drug and Alcohol Dependence Volume 131, Issue 3 , Pages 263-270, 1 August 2013  Abstract
  • Cartwright, Nancy. The Art of Medicine: A Philosopher’s view of the long road from RCTs to effectiveness; the lancet.com Vol. 377 April 23, 2011; 1400 – 1401 Perspective
  • Chaparro,L.E., Andrea D Furlan,A.D., Deshpande,A., Mailis-Gagnon, A. Atlas, S., Turk,D.C. Opioids compared to placebo or other treatments for chronic low-back pain. The Cochrance Library, Intervention Review, August 27, 3013 DOI:10.1002/14651858.CD004959.pub4   Abstract
  • Chen, L. Vo, T. Seefeld, L. et al. Lack of Correlation Between Opioid Dose Adjustment and Pain Score Change in a Group of Chronic Pain Patients. J. Pain. 2013 Feb 26. pii: S1526-5900(12)00985-6. doi: 10.1016/j.jpain.2012.12.012.  Abstract
  • Chou R, Ballantyne JC, Fanciullo GJ, Fine PG, Miaskowski C. Research gaps on use of opioids for chronic noncancer pain: Findings from a review of the evidence for an American Pain Society and American Academy of Pain Medicine clinical practice guideline: J Pain 2009; 10:147-59.
  • Chou R, Clark E, Helfand M. Comparative efficacy and safety of long-acting oral opioids for chronic non-cancer pain: a systematic review. J Pain Symptom Manage 2003; 26:1026-1048.
  • Clauw, Daniel J. MD; Fibromyalgia A Clinical Review. JAMA. 2014;311(15):1547-1555. doi:10.1001/jama.2014.3266. April 16, 2014. Article
  • Coffin, Phillip. MD, MIA;Banta-Green, Caleb PhD. The Dueling Obligations of Opioid Stewardship. Ann Intern Med. Published online 10 December 2013 doi:10.7326/M13-2781.  Editorial 
  • Cottler LB, Abdallah B.A., Cummings SM, Barr J, Banks R, Forchheimer R. Injury, pain, and prescription opioid use among former National Football League (NFL) players. Drug Alcohol Depend. 2011 Jul 1;116(1-3):188-94. doi: 10.1016/j.drugalcdep.2010.12.003. Epub 2011 Jan 28. Abstract
  • Davoli M, et al Risk of fatal overdose during and after specialist drug treatment: the VEdeTTE study, a national multi-site prospective cohort study. Addiction. 2007 Dec;102(12):1954-9. Abstract
  • Des Spence. Evidence based medicine is broken. BMJ 2014;348:g22/10.1136/bmj.g22 (Published 3 January 2014)  Article
  • Des Spence. End the Scandal of free Medical ‘education’BMJ 2013; 346 doi: http://dx.doi.org/10.1136/bmj.f3936.
  • DeVries, Andrea Ph.D.; Koch, Thomas M.D.,M.P.H. et al.  Opioid Use Among Adolescent Patients Treated for Headache. Journal of Adolescent Health published online 26 February 2014. Abstract
  • Deyo, R.A. MD, MPH, Mirza, S.K. Mirza, MD, MPH, Turner,  J.A. PhD, Martin, B.I. MPH. Overtreating Chronic Back Pain: Time to Back Off? DOI: 10.3122/jabfm.2009.01.080102.  J Am Board Fam Med January – February 2009 Vol. 22 no. 1 62-68. Abstract
  • Dhalla, Irfan A. MD MSc FRCPC; Mamdani, Muhammad M. PharmD MA MPH; Gomes, Tara MHSc; Juurlink, David N.  MD PhD FRCPC.  Clustering of opioid prescribing and opioid-related mortality among family physicians in Ontario. Canadian Family Physician March 2011 vol. 57 no. 3 e92-e96. Abstract
  • Dhalla IA, Mamdani MM, Sivilotti MLA, Kopp A, Qureshi O, Juurlink DN. Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting Oxycodone. CMAJ 2009; 181 (12).
  • Dhalla IA, Persaud N, Juurlink DA.  Facing up to the prescription opioid crisis.  British Medical Journal, August 2011. Link to Study (PDF)
  • Dhalla, Irfan MD,  Laupacis, Andreas MD MSc  Moving from opacity to transparency in pharmaceutical policy. CMAJ. 2008 February 12; 178(4): 428–431.doi:  10.1503/cmaj.070799
  • Doe, John. My Story: How one Percocet Prescription Triggered my Addiction. Journal of Medical Toxicology, December 2012, Volume 8, Issue 4; 10.1007/s13181-012-0268-5  Article
  • Dormuth, Colin R.  ScD, Miller, Tarita A. BSc, Huang, Anjjie MSc, Mamdani, Muhammad M. PharmD MPH, Juurlink, David N. MD PhD.  Effect of a centralized prescription network on inappropriate prescriptions for opioid analgesics and benzodiazepines. CMAJ November 6, 2012 vol. 184 no. 16 First published September 4, 2012, doi: 10.1503/cmaj.120465.  Research
  • Dowell, D., Kunins, H.V., Farley, T.A., Opioid Analgesics — Risky Drugs, Not Risky Patients.JAMA. May 9, 2013;():1-2. doi:10.1001/jama.2013.5794.   Article
  • Doyon, S., Aks, S. E., and Scheffer, S.  POSITION STATEMENT - Expanding access to naloxone in the United States. Clinical Toxicology. October 6, 2014. (doi:10.3109/15563650.2014.968657) Abstract
  • Dunn KM, Saunders KW, Rutter CM, Banta-Green CJ, Merrill JO, Sullivan MD, Weisner CM, Silverberg MJ, Campbell CI, Psaty BM, Von Korff M. Opioid prescriptions for chronic pain and overdose: a cohort study. Annals of Internal Medicine 2010; 152:85-92.
  • Dye, L.R. Getting Good or Getting Well. Journal of Medical Toxicology, American College of Medical Toxicology 2012, 10.1007/s13181-012-0265-8. Article
  • Edlund, MJ., Martin BC, Russo JE, DeVries, A., Braden JB., Sullivan, MD.  The role of opioid prescription in incident opioid abuse and dependence among individuals with chronic noncancer pain: the role of opioid prescription.  Clin J Pain. 2014 Jul;30(7):557-64. doi: 10.1097/AJP.0000000000000021.  Abstract
  • Elliott, Carl.  Relationships between physicians and pharma: Why Physicians Should Not Accept Money from the Pharmaceutical Industry, Neurology Clinical Practice 2014;4;164-167. Article
  • Fanga, Ferric C., Steenc, R. Grant and Casadevalld, Arturo.  Misconduct accounts for the majority of retracted scientific publications.  Proceedings of the National Academy of Sciences of the United States of America, PNAS vol. 109 no. 42 > Ferric C. Fang,  17028–17033, doi: 10.1073/pnas.1212247109. Abstract
  • Fiellin DA, Schottenfeld RS, Cutter CJ, Moore BA, Barry DT, O’Connor PG. Primary Care-Based Buprenorphine Taper vs Maintenance Therapy for Prescription Opioid Dependence: A Randomized Clinical Trial. JAMA Intern Med. 2014 Oct 20. doi: 10.1001/jamainternmed.2014.5302. [Epub ahead of print]  Abstract
  • Fischer B., Jones W., Rehm J. High correlations between levels of consumption and mortality related to strong prescription opioid analgesics in British Columbia and Ontario, 2005 – 2009. Pharmacoepidemiol Drug Saf. 2013 Jan 14. doi: 10.1002/pds.3404. Abstract
  • Flaherty, Dennis K. PhD. Ghost- and Guest-Authored Pharmaceutical Industry-Sponsored Studies: Abuse of Academic Integrity, the Peer Review System, and Public Trust (July/August). The Annals of Pharmacotherapy, Published online before print June 26, 2013, doi:10.1345/aph.1R691  Abstract   Commentary
  • Franklin, G.M. MD,MPH.  Opioids for Chronic Non Cancer Pain: A Position Paper of the American Academy of Neurology. Neurology; 83;1277 – 1284. Article
  • Franklin GM, Wickizer TM, Coe NB, Fulton-Kehoe D.  Workers’ compensation: Poor quality health care and the growing disability problem in the United States.  Am J Ind Med. 2014 Oct 20. doi: 10.1002/ajim.22399.  Abstract
  • Franklin GM, Fulton-Kehoe D, Turner JA, Sullivan MD, Wickizer TM. Changes in Opioid Prescribing for Chronic Pain in Washington State J Am Board Fam Med. 2013 July-August;26(4):394-400.  Abstract
  • Franklin GM, Mai J, Turner J, Sullivan M, Wickizer T, Fulton-Kehoe D. Bending the prescription opioid dosing and mortality curves: impact of the Washington State opioid dosing guideline. Am J Ind Med. 2012 Apr;55(4):325-31. doi: 10.1002/ajim.21998. Abstract
  • Frank, Cassie et al. Era Of Faster FDA Drug Approval Has Also Seen Increased Black-Box Warnings And Market Withdrawals. Health Affairs, Vol. 33 No.8 August, 2014. Abstract
  • Fugh-Berman A.  (November 19, 2013) How Basic Scientists Help the Pharmaceutical Industry Market Drugs. PLoS Biol 11(11): e1001716. doi:10.1371/journal.pbio.1001716 Article
  • Fugh-Berman, Adriane; Ahari, Shahram. Following the Script: How Drug Reps Make Friends and Influence Doctors. PLOS Medicine 2007 April; 4(4): e150.  Article
  • Gaskell H., Moore RA., Derry S., Stannard, C.  Oxycodone for neuropathic pain and fibromyalgia in adults. Cochrane Database Syst Rev. 2014 Jun 23;6:CD010692. doi: 10.1002/14651858.CD010692.pub2.  Abstract
  • Gatchel, R.J.,  McGeary, D.D., McGeary, C.A., Lippe, B.  Interdisciplinary Chronic Pain Management: Past, Present and Future. American Psychologist, February, March 2014. Article
  • Gelfand, Stephen G. MD, FACP, FACR.  Comment on the “fibromyalgia” label: More cons than pros.  American College of Rheumatology,  Arthritis Care & Research - Volume 49, Issue 1, page 144, 15 February 2003. Letter
  • Godlee, Fiona. How guidelines can fail us.  BMJ 2014; 349 doi: http://dx.doi.org/10.1136/bmj.g5448 (Published 04 September 2014) BMJ 2014;349:g5448.  Abstract
  • Gøtzsche, Peter C.  Why I think antidepressants cause more harm than good.  The Lancet Psychiatry, Volume 1, Issue 2, Pages 104 – 106, July 2014.  Abstract
  • Goldacre, Ben MD. Guidelines for collaboration with industry should be transparent.  BMJ 2013;347:f6100 (Published 9 October 2013) Article
  • Gomes T, Juurlink D, Yao Z, Camacho X, Paterson M, Singh S, Dhalla I, Sproule B, Mamdani M.  Impact of a prescription monitoring program on the prevalence of potentially inappropriate prescriptions for monitored drugs.  CMAJ Open. 2014; Nov 18.  Abstract (external publication)
  • Gomes, T. MHSc; Mamdani, Muhammad M.,PharmD MA MPH; Paterson, J. Michael, MSc; Dhalla, Irfan A. MD MSc; Juurlink, David N. MD PhD; Trends in high-dose opioid prescribing in Canada. Canadian Family Physician September 2014 vol. 60 no. 9 826-832. Article  Abstract
  • Gomes, T. MHSc; Redelmeier, D.A. MD; Juurlink, D.M. MD, PhD; Dhalla, I.A., MD, MSc; Camacho, X. MMath; Mamdani, M.M. PharmD, MA, MPH. Opioid Dose and Risk of Road Trauma In Canada A Population-Based Study. JAMA Intern Med. 2013;173(3):196-201. doi:10.1001/2013.jamainternmed.733.  Link
  • Gomes, T. Mamdani, M.M., Dhalla, I.A., Paterson, J.M., Juurlink, D.M. Less is more: Opioid dose and drug-related mortality in patients with nonmalignant pain. Arch Intern Med. 2011;171(7):686-691. doi:10.1001/archinternmed.2011.117.
  • Gomes T, Juurlink DN, Dhalla IA, Mailis-Gagnona A, Paterson JM, Mamdani MM. Trends in opioid use and dosing among socio-economically disadvantaged patients. Open Medicine, Vol 5, No 1 (2011).
  • Gomes T, Juurlink DN, Moineddin R, Gozdyra P, Dhalla I, Paterson JM, Mamdani MM. Geographical variation in opioid prescribing and opioids-related mortality in Ontario. Healthcare Quarterly 2011; Vol. 14(1): 22-24.
  • Goodman, A. µ-Opioid Receptors Impaired in Fibromyalgia Patients, Study Shows. Clinical Pain Medicine. ISSUE: MARCH 2013 | VOLUME:  Abstract
  • Greene, Jeremy A. MD, PHD and Herzberg, David PHD.  Public Health Then and Now: Hidden in Plain Sight –  Marketing Prescription Drugs to Consumers in the Twentieth Century. American Journal of Public Health, May 2010, Vol. 100  No. 5 Article
  • Gussow, Leon. Toxicology Rounds The Dark Truth Behind Pain as the Fifth Vital Sign. Emergency Medicine News, March 2013 – Volume 35 – Issue 3 – p4-5; doi:10.1097/01.EEM.0000428252.40340.9a  Link to article
  • Habibi, Roojin; Lexchin, Joel. Quality and Quantity of Information in Summary Basis of Decision Documents Issued by Health Canada. Plos One, March 20, 2014DOI: 10.1371/journal.pone.0092038  Article
  • Hayden A, Hayashi K, Dong H, Milloy MJ, Kerr T, Montaner JS, Wood E. The impact of drug use patterns on mortality among polysubstance users in a Canadian setting: a prospective cohort study.  BMC Public Health. 2014 Nov 6;14:1153. doi: 10.1186/1471-2458-14-1153. Abstract
  • Heath, Iona. Overdiagnosis: when good intentions meet vested interests—an essay by Iona Heath.  BMJ 2013; 347 doi:10.1136/bmj.f6361 (Published 25 October 2013) Abstract
  • Hicks, Caitlin W., Makary, Martin A. Christmas 2013: Medical Histories - A prophet to modern medicine – Ernest Amory Codman. BMJ 2013; 347 doi: http://dx.doi.org/10.1136/bmj.f7368 (Published 18 December 2013). Article 
  • Hirsch, Anne MPH, Proescholdbell, Scott K. MPH,* Bronson, William BA, CSAC, Dasgupta, Nabarun MPH, PhD. Prescription Histories and Dose Strengths Associated with Overdose Deaths. Pain Medicine, Wiley Online Library. DOI: 10.1111/pme.12391; February 15, 2014. Abstract
  • Honald, Katherine M. Side Effects From Oral Opioids in Older Adults During the First Week of Treatment for Acute Musculoskeletal Pain. Academic Emergency Medicine Volume 20, Issue 9, pages 872–879, September 2013.  Abstract
  • Hwang, Catherine S. MSPH; Turner, Lydia W. MHS; Kruszewski, Stefan P. MD; Kolodny, Andrew MD; Alexander, G. Caleb MD, MS. Prescription Drug Abuse A National Survey of Primary Care Physicians.  JAMA Intern Med. Published online December 08, 2014. doi:10.1001/jamainternmed.2014.6520.  Research Letter
  • Ioannidis, J.P.A. How Many Contemporary Medical Practices Are Worse Than Doing Nothing or Doing Less?

    Stanford Prevention Research Center, Department of Medicine, and Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA Department of Statistics, Stanford University School of Humanities and Sciences, Stanford, CA published online 22 July 2013.

    Article

  • Ioannidis, John P.A.  Why Most Published Research Findings Are False. PLOS Medicine Published: August 30, 2005DOI: 10.1371/journal.pmed.0020124. Abstract
  • Inocencio TJ, Carroll NV, Read EJ, Holdford DA. The Economic Burden of Opioid-Related Poisoning in the United States.     Pain Med. 2013 Jul 10. doi: 10.1111/pme.12183. Abstract
  • Ivers, N., Dhalla, I., Allan, M. Link to article Opioids for osteoarthritis pain: benefits and risks. 2013 The College of Family Physicians of Canada.
  • Jain, Anita; Nundy, Samiran; Abbasi, Kamran. Corruption: Medicine’s dirty open secret. BMJ 2014;348:g4184.  June 25, 2014.  Editorial
  • Jeffery DD, May L, Luckey B, Balison BM, Klette KL. Use and Abuse of Prescribed Opioids, Central Nervous System Depressants, and Stimulants Among U.S. Active Duty Military Personnel in FY 2010.  Mil Med. 2014 Oct;179(10):1141-8. doi: 10.7205/MILMED-D-14-00002.  Abstract
  • Johnson EM, Lanier WA, Merrill RM, Crook J, Porucznik CA, Rolfs RT, Sauer B. Unintentional Prescription Opioid-Related Overdose Deaths: Description of Decedents by Next of Kin or Best Contact, Utah, 2008-2009. J Gen Intern Med. 2012 Oct 16. Abstract
  • Jones, C.M. PharmD, Mack, K.A. PhD, Paulozzi, L.J. MD. Pharmaceutical Overdose Deaths, United States, 2010.  JAMA. 2013;309(7):657-659. doi:10.1001/jama.2013.272. Abstract
  • Jones, Christopher W. et al  Non-publication of large randomized clinical trials: cross sectional analysis. BMJ 2013;347:f6104 Abstract
  • Jorgensen, Paul D.  Pharmaceuticals, Political Money, and Public Policy: A Theoretical and Empirical Agenda. University of Texas – Pan American; Harvard University – Edmond J. Safra Center for Ethics. Journal of Law, Medicine and Ethics, Vol. 14, No. 3, 2013.  Abstract/Article
  • Juurlink David N., Dhalla Irfan A., Dependence and Addiction During Chronic Opioid Therapy. American College of Medical Toxicology 2012; J. Med. Toxicol.DOI 10.1007/s13181-012-0269-4.  Abstract
  • Juurlink, D.N. MD, PhD; Dhalla,I.A. MD, MSc; Nelson, L.S. MD. Improving Opioid Prescribing, The New York City Recommendations .JAMA. 2013;309(9):879-880. doi:10.1001/jama.2013.1139. Abstract
  • Kahan, M. MD MHSc CCFP FRCPC et al. Effect of a course-based intervention and effect of medical regulation on physicians’ opioid prescribing. Canadian Family Physician, May 2013. vol. 59 no. 5 e231-e239. Abstract
  • Kapoor S, Thorn BE. Healthcare use and prescription of opioids in rural residents with pain.  Rural Remote Health. 2014 Jul-Sep;14(3):2879. Epub 2014 Sep 9.  Abstract
  • Katz MH. Long-term opioid treatment of nonmalignant pain: A believer loses his faith. Arch Intern Med 2010: 170:1422-4. Abstract
  • Kirschner, N.PhD; Ginsburg, J.;Snyder Sulmasy, L. JD. Prescription Drug Abuse: A Policy Position Paper From the American College of Physicians. Ann Intern Med. Published online 10 December 2013 doi:10.7326/M13-2209. Article 
  • King, Nicholas B. PhD; Fraser, Veronique RN, MSc, Boikos, Constantina MSc, Richardson, Robin MPH, Harper, Sam PhD.  Determinants of Increased Opioid-Related Mortality in the United States and Canada, 1990 – 2013:  A Systematic Review. American Journal of Public Health, June 12, 2014. Review
  • Kissin, I. Long-term opioid treatment of chronic nonmalignant pain: unproven efficacy and neglected safety?  J Pain Res. 2013 Jul 4;6:513-29. doi: 10.2147/JPR.S47182. Print 2013. Abstract     Article
  • Krumholz, Harlan M. MD, SM.  A Note to My Younger Colleagues. . .Be Brave.  American Heart Association –  Cardiovascular Medicine and the Robert Wood Johnson Clinical Scholars Program, Department of Medicine, Yale University School of Medicine; the Section of Health Policy and Administration, Yale School of Public Health; and Center for Outcomes Research and Evaluation, Yale–New Haven Hospital, New Haven, CT.  Article
  • Kuehn, Bridget M. MSJ.  ED Visits for Sedatives Increase.  JAMA. 2014;312(4):328. doi:10.1001/jama.2014.9118. Article
  • Kuehn, Bridget M. MSJ. CDC: Major Disparities in Opioid Prescribing Among States / Some States Crack Down on Excess Prescribing.  JAMA. Published online August 06, 2014. doi:10.1001/jama.2014.9253.  Article
  • Kuehn, Bridget M. MSJ.  AHRQ: Little Evidence for Opioids in Managing Long-term Chronic Pain.  JAMA. 2014;312(12):1185. doi:10.1001/jama.2014.12752.  Article
  • Kunins, H.V., MD, MPH, MS; Thomas,T.A.,MD, MPH; Dowell, D., MD, MPH; Guidelines for Opioid Prescription: Why Emergency Physicians Need Support. Ann Intern Med. 9 April 2013.  Article
  • Ladouceur, Roger. MD MSc CCMF FCMF, ASSOCIATE SCIENTIFIC EDITOR. Opioid dependence, Canadian Family Physician CFP, April 2013 vol. 59 no. 4 333.  Editorial
  • Lank, P.M. Toxicology Fellow’s Perspective: Filling a Void in Medical Education Regarding Opioids. J. Med. Toxicol. (2012) 8:333–334 DOI 10.1007/s13181-012-0271-x. Article
  • Lee, M. MD, Silverman, S. MD, Hansen, H. MD, Patel, V. MD,  Manchikanti, L. MD. A Comprehensive Review of Opioid-Induced Hyperalgesia. Pain Physician March, 2011. 14:145-161  ISSN 1533 – 3159.  Article
  • Lembke, Anna. Why Doctors Prescribe Opioids to Known Opioid Abusers. The New England Journal of Medicine 2012; 367:1580-1581 October 25, 2012DOI: 10.1056/NEJMp1208498.  Why Doctors Prescribe Opioids to Known Opioid Abusers
  • Lenzer, Leanne; Hoffman, Jerome R., Furberg, Curt D., Ioannidis, John P A.  Ensuring the integrity of clinical practice guidelines: a tool for protecting patients. BMJ 2013; 347 doi: http://dx.doi.org/10.1136/bmj.f5535 (Published 17 September 2013) Cite this as: BMJ 2013;347:f5535  Article
  • Liang Y, Turner BJ.  Assessing Risk for Drug Overdose in a National Cohort: Role for Both Daily and Total Opioid Dose? J Pain. 2014 Dec 5. pii: S1526-5900(14)01026-8. doi: 10.1016/j.jpain.2014.11.007. [Epub ahead of print] Abstract
  • Light, D.W., Lexchin, J., Darrow, J.J.  Institutional Corruption of Pharmaceuticals and the Myth of Safe and Effective Drugs.  Journal of Law, Medicine and Ethics, Vol. 14, No. 3, 2013, Forthcoming. June 1, 2013. Abstract 
  • Lutz PE, Kieffer BL. The multiple facets of opioid receptor function: implications for addiction. Curr Opin Neurobiol. 2013 Aug;23(4):473-9. doi: 10.1016/j.conb.2013.02.005. Epub 2013 Feb 28. McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada. Abstract
  • Madadi, P., Hildebrandt, D., Lauwers, A.E., Koren, G., Characteristics of Opioid-Users Whose Death Was Related to Opioid-Toxicity: A Population-Based Study in Ontario, Canada. PLoS ONE 8(4): e60600. doi:10.1371/journal.pone.0060600. Sam Eldabe, The James Cook University Hospital, United Kingdom. April 5, 2013.  Article
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